![]() Jonathan McMaster, Vasily S Oganesyan.Annual Review of Physical Chemistry 2011, 62 Theoretical and Computational Protein Design. MacDermaid, Jose Manuel Perez-Aguilar, Jeffery G. Alteration of the oxygen-dependent reactivity of de novo Due Ferri proteins. Pires, Rae Ana Snyder, Yibing Wu, Hyunil Jo, Daniel W. Journal of the American Chemical Society 2012, 134 Azurin as a Protein Scaffold for a Low-coordinate Nonheme Iron Site with a Small-molecule Binding Pocket. Shafaat, Salvador Peña, Jawahar Sudhamsu, Amy A. McLaughlin, Marius Retegan, Eckhard Bill, Thomas M. Unexpected weak magnetic exchange coupling between haem and non-haem iron in the catalytic site of nitric oxide reductase (NorBC) from Designing functional metalloproteins: From structural to catalytic metal sites. ![]() European Journal of Inorganic Chemistry 2014, 2014Ĭomputational Protein Design. De Novo Designed Copper α‐Helical Peptides: From Design to Function. QM/MM Molecular Dynamics Studies of Metal Binding Proteins. Pietro Vidossich, Alessandra Magistrato.The Journal of Physical Chemistry B 2015, 119 Computational Treatment of Metalloproteins. Biochimica et Biophysica Acta (BBA) - Bioenergetics 2016, 1857 Design of dinuclear manganese cofactors for bacterial reaction centers. Olson, Eduardo Espiritu, Selvakumar Edwardraja, Chad R. Biochimica et Biophysica Acta (BBA) - Bioenergetics 2017, 1858 Biochemical and spectroscopic characterization of dinuclear Mn-sites in artificial four-helix bundle proteins. Olson, Eduardo Espiritu, Selvakumar Edwardraja, Elizabeth Canarie, Marco Flores, JoAnn C. Angewandte Chemie International Edition 2018, 57 Modifying the Steric Properties in the Second Coordination Sphere of Designed Peptides Leads to Enhancement of Nitrite Reductase Activity. Koebke, Fangting Yu, Elvin Salerno, Casey Van Stappen, Alison G. Cross-β amyloid nanotubes for hydrolase–peroxidase cascade reactions. Ayan Chatterjee, Syed Pavel Afrose, Sahnawaz Ahmed, Akhil Venugopal, Dibyendu Das.Crystallographic Analysis of Active Site Contributions to Regiospecificity in the Diiron Enzyme Toluene 4-Monooxygenase. Protein Design: Toward Functional Metalloenzymes. Mocny, Leela Ruckthong, Hira Qayyum, and Vincent L. ![]() Journal of the American Chemical Society 2015, 137 Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins. Systematic Perturbations of Binuclear Non-heme Iron Sites: Structure and Dioxygen Reactivity of de Novo Due Ferri Proteins.
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![]() The DarkFighter camera features a two-megapixel, 1.9 inch high definition progressive scan CMOS image sensor. Competition for these industry-leading awards was very fierce this year with a record number of entries received and our being shortlisted as a finalist is a testament both to the outstanding qualities of the DarkFighter camera and to the innovative approach Hikvision takes to the global CCTV surveillance market." As well as opening up new opportunities for 24-hour CCTV surveillance, it is the ideal replacement for conventional IP network cameras.Īccording to Keen Yao, International Marketing Director at Hikvision, "We are very pleased to see the DarkFighter camera's ultra-low-light sensitivity and unique Smart detection technologies rewarded with this nomination. The result is crystal-clear color images down to 0.0005Lux and the delivery of full color images in conditions that would defeat conventional monochrome IP cameras and competing low-light cameras. ![]() This cutting-edge camera utilizes Hikvision's industry-leading, ultra-low-light MP lens and is designed specifically to capture sharp color and monochrome images in extreme, low-light conditions. Hikvision's ultra-low-light surveillance DarkFighter PTZ camera has been nominated as a finalist for "CCTV Camera Equipment of the Year" in ISFEC's Security & Fire Excellence Awards. Hikvision DS-2DF8223I-A(AEL) delivers full color images in conditions that would defeat conventional monochrome IP cameras and competing low-light cameras As the world's first 1080P Full HD ultra low illumination PTZ network camera. ![]() ![]() ProtonMail's open source software has been thoroughly vetted by security experts from around the world to ensure the highest levels of protection. By using open source libraries, we can guarantee that the encryption algorithms we are using do not have clandestinely built in back doors. Furthermore, all of the cryptographic libraries we use are open source. Demo showing email cryptography End-to-end encryption means that no one but the intended recipient can read the message Open Source Cryptography Time-tested and trusted encryption algorithms We use only secure implementations of AES, RSA, along with OpenPGP. If you forget your password, we cannot recover your data. For this reason, we are also unable to do data recovery. With ProtonMail, privacy isn't just a promise, it is mathematically ensured. This means we don't have the technical ability to decrypt your messages, and as a result, we are unable to hand your data over to third parties. Data is encrypted on the client side using an encryption key that we do not have access to. Zero Access to User Data Your encrypted data is not accessible to us ProtonMail's zero access architecture means that your data is encrypted in a way that makes it inaccessible to us. Let us know if you do something cool with our code. As a nod to our CERN and MIT roots, we are releasing under the permissive MIT license. Mail and Calendar is ranked 2nd while Opera Mail is ranked 12th. In the question What are the best e-mail clients for Windows. ProtonMail 2.0 can be viewed online on Github at the link below. When comparing Opera Mail vs Mail and Calendar, the Slant community recommends Mail and Calendar for most people. As we continue to expand our private email service with mobile apps, you can look forward to more open source announcements as our code base matures. ![]() By open sourcing ProtonMail 2.0, we are open sourcing the future of ProtonMail. While it would have also been possible to open source ProtonMail 1.x, we felt that such a move was not appropriate given that the code was intended to be deprecated. Our move to open source has actually been coming for a long time. We hope that by opening up our platform, we will encourage additional contributors to help us make ProtonMail the world’s most secure email service. This means all the ProtonMail code that runs on your computer is now available for inspection. Today, we are happy to take the next step and completely open source our webmail interface. We are happy to announce that we are also releasing ProtonMail 2.0 as open source software! From the beginning, we have been strong proponents of open source software and the core cryptography libraries that we develop and use have been open source from day one. ![]() ![]() ![]() With the HCP Quant strategy, the portfolio is exposed to positive impacts in the future with a high probability. In investing, nothing is certain, but some scenarios are more likely to happen than others. In this article Frank takes a look at how early-stage quantitative hedge fund managers can go about looking to secure their first institutional allocation of. My strengths in investing are a strong understanding of probabilities and being rigidly systematic. It comes naturally to me to form a comprehensible and usable concept from complex and chaotic things. View your Mutual Fund portfolio like a PRO Now view your portfolio across all the Mutual Funds on a single platform Slice and dice your assets based on asset. The investment strategy employed in the HCP Quant fund combines computer modelling and financial theory. The book offers building blocks to improve one’s personal finances through different saving and investing methods. In my first book “Erilainen ote omaan talouteen – Vapaus, onni ja hyvä elämä” (A different take on personal finance – freedom, happiness and good life), which was published in 2014, I cover the relationship between money and happiness and discuss the role that money and consumption play in our lives. Quant Value Fund Direct - Growth has 516 Crores worth of assets under management (AUM) as on and is small fund of its category. This fund has been in existence for 10 m, having been launched on. In 20, Cision, which is a leading global provider of media solutions, ranked my blog “Kohti taloudellista riippumattomuutta” (Towards financial independence) as the second most popular economics blog in Finland. Quant Value Fund Direct - Growth is a Value Oriented mutual fund scheme from Quant Mutual Fund. I am the author of one of the most popular investing blogs in Finland. ![]() The series details the chronological timeline of Berkowitz’s haunting crimes and the subsequent obsessive rabbit-hole that journalist Terry goes down in, while attempting to prove the presence of potential accomplices who might have been roaming around scott-free, committing more crimes.Īnother famous ‘crime scene’ you should visit virtually is through the Netflix series, The Confession Killer. Dubbed as the ‘point 45-caliber killer’, owing to the namesake revolver gun he used to kill his seemingly random victims, the postal employee Berkowitz was caught in 1977 for terrorising the city of New York for over a year. The chilling crimes took place in the Bronx, Brooklyn and Queens in New York, in the 1970s. Not only this, he believed that the murders were linked to a satanic cult. The true crime series dives deep into the mind of investigative journalist Maury Terry, who was convinced that the serial killer, David Berkowitz, had accomplices in the six murders and seven attempted murders he committed in the ‘Son of Sam’ case. His real-life case and subsequent popularity inspired several gripping true crime documentaries and movies.Ī gripping four-part docuseries, The Sons Of Sam: A Descent Into Darkness, is another series added to the impressive true crime-themed catalogue that Netflix boasts. Including Bundy’s notorious blood-curling interviews and rare video and audio footage from the archives, recorded when he was on death row, Conversations With a Killer: The Ted Bundy Tapes offers a blistering portrait of the heartless killer.ĭespite the horrific nature of his crimes, Bundy had sort of turned into a celebrity and was sensationalised due to his charming looks and witty interactions with the court and the media, especially after his 1977 escape from custody in Colorado, US. Bundy denied his crimes for over a decade before he confessed to committing 30 murders over the course of several years in the early ‘70s. Remembered as one of the most ‘handsome and charming’ criminals in the history of true crime, Conversations With a Killer: The Ted Bundy Tapes is perfect for a weekend binge, if you want to gain some insight into the mind of a horrendous criminal and decode his murders.īorn in 1946, Theodore Robert Bundy was an American serial killer who murdered, kidnapped and raped several innocent young women in the 1970s. ![]() Not for the faint-hearted, Night Stalker is one of the best Netflix true crime documentaries to binge on during the weekend. It includes detailed accounts of their interactions with Ramirez, chilling archival footage, upsettingly graphic crime scenes and eerie cinematography. ![]() This limited docu-series hauntingly shows how the homicide investigators decode the murders and hunt down the serial killer to bring him to justice. In this Netflix crime series, two homicide detectives, Gil Carrillo and Frank Salerno race against time to nab the Night Stalker for committing close to 15 heinous murders and sexual assaults. Ramirez was a notorious murderer, kidnapper, rapist, child molester, and burglar who lurked under the glamorous facade of sunny California and committed these nocturnal atrocities in the 1980s. Born in 1960 and dubbed as the Walk-in Killer and Night Stalker of Los Angeles in the United States, Ricardo ‘Richard’ Leyva Muñoz Ramírez, has been a subject of several movies and a true crime docu-series on Netflix, based on his unthinkable crimes. ![]() ![]() Combat(Attack/Defence/Strength/Health)/Range/Magic (you need lvls to deal damage) Fishing/Cooking(For food suplies when you fight) Mining/Smithing(For weapons) Herblore(For prayer potions and others) Fletching(For ranger supplies) RuneCraft(For runes. Another more safe way is dueling, no interuptions you can set the rules and you have a choice over what items are at risk. The more benefiting way would be to go to wildy the loot from there varies depending on the player you kill, it may be more dangerous but its worth it. ![]() The easiest would be to kill monsters but the loot from monsters is very limited. = 3) FAQ = (None so far email me and I will add your questions) = 4) The Guide! = Ok here is the guide jsut jump to the part with your skill and check if there are any ways there. Combat skills and prayer will also be helpful in many cases. Its is advised that you have a basic understanding of RuneScape and atleast a couple of your skills up to 50. = 1) Updates = 1.0 JanuI made this guide today! = 2) Information = This guide is for RuneScape Money making. _/\_/ _/_/_ Money Making Guide! 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We were able to detect the BitTorrent protocol in our internet traffic while torrenting without a VPN. ![]() Your internet traffic is made up of small bits of data called ‘packets’ that establish a communication channel between your device and the server you’re accessing.ĭeep packet inspection allows your ISP to analyze the individual packets that make up your Your ISP can monitor the content of your traffic through a process called deep packet inspection. ISPs can collect the IP addresses of well-known streaming services and video game servers and throttle any traffic that attempts to connect to them. ISPs can monitor your browsing history, and some are actively looking to throttle activities that consume large amounts of bandwidth, including: streaming, online gaming, and P2P file sharing. Throttling Based on the Websites You Access This differs from a ‘hard’ data cap which prevents an internet connection from being created. If your ISP actively enforces a bandwidth limit then you’ll need to upgrade to a more generous plan or switch providers.ĪT&T lowers your connection speed if you exceed the set data limit.įor example, AT&T allows customers who exceed their data cap either operate on slower connection speeds or pay for a higher allotment of data. ![]() For example, if your ISP sets your bandwidth limit to 50Mbps, then it would take 20 seconds to download a 1GB (1,000MB) file.Īs with data caps, you can’t bypass bandwidth limits. Similar to a data cap, a bandwidth limit refers to a fixed volume of data that can be transferred over a period of time. You can also switch to an ISP that doesn’t use data plans. You can, however, upgrade to a data plan with a higher allotment or subscribe to an unlimited data plan without any restrictions. Unfortunately, it is impossible to bypass a data cap, as your ISP will always be able to monitor the amount of data you use. 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This tourist mecca is voted one of the best islands in the world year after year. To start planning your trip, read my budget travel guide to Ko Lipe! The best way to get there is by boat from Pak Bara.īEST PLACE TO STAY IN KO LIPE: The Chic Lipe – A boutique hostel with a restaurant on-site that’s just a short walk to Walking Street and Sunrise Beach. May through October sees a harsh monsoon season that shuts the island down. Visit between November and March for the best weather and the fewest people. Bathtub-warm water and fine sand beaches kept me here for over three weeks. I expect development will slowly erode this paradise, however, so visit soon!Ĭlose to this island is a little island that provides excellent snorkeling opportunities. Accommodation is still basic, though more and more places now offer electricity 24/7. Here on Ko Lipe, the super-friendly locals bring in the daily catch for amazing seafood, as the island’s water is teeming with life. Located in southern Thailand, this semi-off-the-map island is one of my favorites and the month I spent here remains one of my most fond memories. To start planning your trip, read my budget travel guide to the Maldives! June through October sees wetter and hotter weather due to the monsoon season.īEST PLACE TO STAY IN THE MALDIVES: Sands Exotic Hotel (Thulusdhoo) – A budget-friendly hotel near the beach that includes free breakfast and basic amenities like flatscreen TVs and AC. The best time to go to the Maldives is from November to May when the weather is cool and dry. Luckily, Bangkok Airways offers cheap flights to and from Thailand (you can find round-trip flights for under $300 USD!). Private resorts litter the islands, and a vacation here is also very pricey. These little coral islands are surrounded by excellent diving, snorkeling, and idyllic white-sand beaches, and are filled with friendly locals. The government has built flood barriers to help lessen the impact of any future tsunamis though it’s going to be one of the first nations to feel the pressure of climate change. During the 2004 Tsunami, many of these islands were completely washed away. The country is actually just a series of coral atolls that are barely above sea level. Located in the middle of the Indian Ocean, the Maldives is a chain of 1,000 islands (200 are inhabited, and only 5 have any substantial population). To start planning your trip, read my budget travel guide to the Seychelles! Reef Safari at St Anne Marine National ParkīEST PLACE TO STAY IN THE SEYCHELLES: Jeanny’s Apartments – A beachfront three-star hotel on Grand’Anse Praslin with free breakfast, free parking, and lovely staff.The best time to visit is during the cool season from May to September when it rains less. ![]() Sadly, these islands are pretty expensive - though it is possible to visit on a budget if you plan ahead. This group of 115 islands offers everything a beach lover could ask for. Seychelles is my dream and should be yours, too. Perfect beaches, perfect water, tons of islands to choose from, and all the seclusion you could want. If anywhere in the world would convince me to give it all up and live in a beach hut, Seychelles would be it. Located off the east coast of Africa, these islands are pure paradise. Here’s a quick overview of the islands in case you’re looking for something specific: ![]() After over a decade of travel and countless hours staring out into the ocean, I’ve done the “hard” research so you don’t have to! I’ve been to many of the best tropical islands in the world (and there are so many of them). Having grown up in Boston and spent many years living in New York City, one of the main purposes of my travels is to avoid winter. The sun and I get along quite well and there’s nothing I’d rather do than live on a tropical island someday. I spent a month living on an island in Thailand and it remains one of the best months of my entire life. Tropical islands are that peaceful escape where the days drift by, the problems of the world melt away, and time slows down. Lounging with a good book, drinking from coconuts, soaking up the rays. When most people think of paradise, chances are they’re thinking of tropical islands is far-flung corners of the world. As soon as I think of travel, it’s not long before my mind drifts to white sand beaches, azure blue water, and palm trees in tropical locales. But I think the movie made it clear that Neil had been unhappy for a long time. I agree that the suicide was a waste of life. And yeah, both Ethan Hawke and Robert Sean Leonard had such baby faces. I'm glad he was strong enough to stand up for Keating at the end and hope he kept that strength and made a great life for himself. The two people who had gotten him out of his shell and appreciated him for who he was were gone. The person I feel the most sorry for is Todd. But, yeah, I hope the dad spends the rest of his miserable life feeling guilty as hell. ![]() It being the 50s, kind of understandable. ![]() She was just unable to stand up to her husband. So have fun rotting in the miserable childless hell you've creating for yourselves, assholes.Īgreed on his dad. Anyone with eyes could have seen that Neil had been miserable for years and his parents made it worse. Mainly cause there is a chance I would fail the jump or fall off the table.Īnd while I know it's horrible to wish losing a child on anyone, Neil's parents deserved it. As a teacher today I can tell you there is no way in hell I would that. It got ticked with zero comment made about the ridiculousness of it. So in response to being given the scenario about a rowdy class of kids who aren't paying attention to anything, I decided to write that I would jump on the desk and shout some stupid thing. I had a feeling that the lecturer wasn't actually reading the educational diary/journal/reflection thing we had to keep. Having said that I do remember referencing the scene where Robin Williams jumps up on a desk to get the class attention during my uni days in my teaching degree. ![]() Poor little 10 year old me could not handle the fact that someone actually stayed dead when they died in a movie. My innocent mind couldn't handle the suicide, he was meant to come back as a twist and explain that it was all a hoax. First movie I ever saw where things didn't end happily. Do not ask me why but it was the movie chosen to be shown at a slumber birthday party and I was about 10 I reckon. I have only seen the movie once, and it traumatised me. |
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